The sixth and seventh of the seven deadly sins of obesity: Poor bone development and tumor risk in children.

The sixth of the seven deadly sins of obesity: poor bone development in children.

Qingqing, a nurse at the children's hospital, has a 3-year-old son, but due to her and her husband's work...

Both are quite busy, so the child is usually cared for by the child's grandmother. Qingqing and her mother-in-law have a harmonious relationship.

However, they have significant disagreements regarding raising children. The mother-in-law wants to give her everything that's good to eat.

She wasn't relieved until her grandson finished all his food. Qingqing thought this would lead to overnutrition and obesity in the child.

Being overweight affects a child's growth and development. Qingqing's mother-in-law, however, disagreed, always believing that children are simply growing.

A person needs to eat a lot to get good nutrition so they can grow taller and smarter in the future.

Many parents today, like Qingqing's mother-in-law, believe that it's good for children to eat more, and that being a little chubby means...

Good nutrition is beneficial for a child's growth and development. This is actually a misconception.

Excessive weight gain leading to childhood obesity can cause many health problems. Obesity not only affects a child's intelligence but also...

Development can also increase their risk of cardiovascular diseases such as hypertension, dyslipidemia, and coronary artery abnormalities.

And the risk of metabolic diseases such as diabetes. Among these, obesity leads to poor bone development in children.

A typical negative impact.

Children's bones, cartilage, and joints are very fragile during their growth and development. Being overweight can negatively impact a child's bones.

The system is a heavy burden, especially for obese children, who are almost entirely supported by their bones.

They bear a weight close to that of an adult. Although obese children experience earlier bone development, they still face the challenge of being overweight.

Even with body weight, it's still difficult to bear. Excessive weight causes bone pain, limited mobility, and even bone fractures.

Necrosis. These conditions can restrict the activity of obese children, and reduced activity can further exacerbate obesity.

Modern epidemiological studies have found that obese children, due to increased weight-bearing on their bones and joints, have excessively large joints.

Weight gain can cause damage to the growth plate, leading to slipped femoral epiphysis, genu valgum, tibialis varus, and patellar tendonitis.

Bone pain, flat feet, forward vertebral tilt, scoliosis, and osteoarthritis. Childhood obesity is also a contributing factor.

The underlying and major risk factors for osteoarthritis in adults.

Obesity and several sudden changes in governance

In adults, because the weight load is mainly concentrated on the medial cartilage of the knee joint, knee joint degeneration occurs.

Later, genu varum (knock-knees) often develops, commonly known as O-shaped legs. However, children are born with physiological genu valgum (outer knee).

X-shaped legs, commonly known as knock-knees, usually correct themselves as the body develops before school age.

If a child is overweight, genu valgum (knock-knees) will not only fail to correct itself, but its severity will gradually increase.

Obese children are also heavier; at the same time, their lower limb muscle strength and tone are relatively weak, and their ability to control eversion is also reduced.

Poor. Therefore, genu valgum is more common in obese children.

Ba Wutong Yixiao Femoral Head Ischemic Ring Necrosis

The incidence of avascular necrosis of the femoral head in children is about 1% in my country, and it is most common in children aged 4 to 10 years.

Clinically, obese children are more frequently found to have this condition because it places excessive stress on their bones, leading to damage to the femoral head.

The greater gravity they bear can lead to insufficient blood supply to certain areas. Additionally, obese children often have high blood lipids and high blood viscosity.

High blood pressure can also easily cause slow blood flow and stagnation, resulting in insufficient blood supply to the femoral head artery.

Traumatic slipped epiphysis of the femoral head often leads to avascular necrosis of the femoral head. Obese children's sexual...

Due to a relative deficiency of hormones, the cartilage plates at the weakest point of the metaphysis are more fragile and prone to slippage.

At the same time, it increases the force acting on the growth plate, causing growth disorder of the epiphyseal plate.

Obese children are more prone to lumbar disc herniation

The intervertebral disc consists of three parts: the nucleus pulposus, the annulus fibrosus, and the cartilaginous endplate. It is a cushion-like structure with a relatively high water content.

It has a highly elastic structure. As pressure increases, its thickness decreases; when it becomes thinner, the intervertebral disc only...

It can bulge outwards. Under the influence of external forces, degeneration, and other factors, the annulus fibrosus can further break.

When the nucleus pulposus prolapses, it compresses the spinal nerve roots and cauda equina posteriorly, causing a series of symptoms such as lower back pain and leg pain.

symptom.

In the past, many people thought that lumbar disc herniation was a disease that mainly affected young adults, but...

In recent years, lumbar disc herniation has become increasingly common among adolescents, especially obese children.

Obese children, due to their greater weight, experience relatively more stress, thus increasing their risk of lumbar spine problems compared to children of normal weight.

The risk of intervertebral disc herniation is higher. In addition, obese children often have poor posture and habits, such as a lack of exercise.

Being active and spending long hours sitting in front of the TV or computer can also have adverse effects on the lumbar intervertebral discs.

In addition, childhood obesity can affect the production of fat-soluble vitamins A, D, and E due to lipid metabolism disorders.

K absorption can lead to fatty liver, causing digestive disorders, anorexia, loss of appetite, abdominal distension, and abdominal pain.

Diarrhea affects the absorption of calcium and phosphorus, so obese children are highly susceptible to vitamin D deficiency rickets, leading to...

Osteoporosis, abnormal bone development, etc.

Fat**"** **Earth** **Supreme** **Part Seven---**

**swell**

Obesity is a risk factor for foot malignancy.

One of Wenwen's classmates' father was diagnosed with cancer, and Wenwen and her other classmates went to visit him.

The sight of her classmate's father looking haggard and ill, and the worry on her classmate's face, made Wenwen feel uneasy. Wenwen returned...

After getting home, I decided to go online to learn about cancer and see what cancer prevention measures are available.

Remind your family to pay attention to this. During her research, Wenwen saw that obesity can trigger...

She was puzzled by the occurrence of the tumor; her classmate's father, lying in the hospital bed, looked so thin.

Is there really a link between obesity and cancer?

The answer is yes. The classmate Wenwen saw had a father who had been suffering from cancer for some time; cancer itself...

It's a wasting disease that causes significant weight loss during its course. As for tumors, actually...

We are all familiar with cancer; its severity and mortality rate make it a dreaded disease. However, few realize that simple everyday occurrences can...

Obesity alone can increase the risk of cancer.

In 2007, the World Cancer Research Fund and the American Association for Cancer Research published a report on obesity and tumors.

A summary of perspectives on the connections between tumors, illustrating the connections found between colorectal cancer, esophageal cancer, and postmenopausal breast cancer.

There is strong evidence linking kidney cancer and endometrial cancer to fat accumulation in the body.

Colorectal cancer is now associated with abdominal fat accumulation; gallbladder cancer and premenopausal breast cancer are also linked to obesity.

There is a high probability of a link; it is possible that lung cancer and liver cancer are associated with obesity.

A US BMI survey

Large prospective studies have shown a positive correlation between obesity and mortality rates from many cancers. This is particularly evident in male cancer patients.

Among cancer patients who died, obesity was a contributing factor in 14% of deaths, while in female cancer patients...

It accounts for 20%.

Intestinal health: Colorectal cancer is the fourth leading cause of cancer-related death worldwide. (International Association for Cancer Research)

Reports indicate a positive correlation between body fat and the risk of colorectal cancer. Two meta-analyses also found...

There is a significant association between increased colorectal cancer incidence and BMI. The evidence for rectal cancer is less conclusive.

Some studies have found weaker positive relationships.

2) Store: Breast cancer is the leading cause of cancer death among women worldwide, causing more than 500,000 deaths annually.

Women die from breast cancer. A meta-analysis found that for every 5 kg increase in body fat, the risk of postmenopausal breast cancer is higher.

The risk increases by 5%. A multinational collaborative research team on hormone-related factors in breast cancer points out that BMI increases by 5%.

An increase of 1 kg/m² is associated with a 3.1% increased risk of breast cancer. In the prospective nurses' health survey, the absolute...

Postmenopausal increase in body fat is directly associated with breast cancer risk. Compared to women with stable body fat percentages, those with increased body fat are more likely to develop breast cancer.

Reducing body fat mass can significantly lower the risk of breast cancer. Based on this data, some scholars have estimated...

24% of postmenopausal breast cancer cases are attributed to increased body fat.

Dry-office: Most risk factors for endometrial cancer are related to excessive estrogen, obesity

Obesity is one of the risk factors. Studies have shown that for every 5 kg/m² increase in BMI, the risk of uterine fibroids increases.

The risk of endometrial cancer increases by 52%, while for young women, every 5 kg/m² increase in BMI reduces the risk of endometrial cancer.

The risk increased by 31%, indicating that BMI changes beginning in youth play a significant role in this analysis.

In addition, the waist-to-hip ratio is an indicator of central obesity and also an independent risk factor for endometrial cancer.

Risk factors.

(A related study found that obesity is positively correlated with the incidence and mortality of renal cell carcinoma. This finding is supported by research.)

The report states that increased body fat mass in patients aged 18-50 is positively correlated with the risk of renal cell carcinoma, and is greater than [missing information].

Increased body fat at age 50 was not significantly associated with renal cell carcinoma. A case-control study reported...

Men with a BMI > 30 kg/m² have a 2.5 times higher risk of developing renal cell carcinoma than men with a BMI < 20 kg/m².

The sex ratio is 3.3 times.

After age 20, for every 1 kg/m² increase in BMI, the risk of esophageal adenocarcinoma increases by 14%.

The risk of esophageal adenocarcinoma is 3.4 times higher in individuals with a BMI increase of ≥8 kg/m² compared to those with a BMI increase of 0–3.9 kg/m².

Subsequent studies also found that abdominal obesity and fat accumulation increase the risk of esophageal adenocarcinoma.

High BMI is also associated with cardia (the junction of the esophagus and stomach) adenocarcinoma, but abdominal obesity is less associated with cardia adenocarcinoma.

It is not related to hilar adenocarcinoma.

6.1 Prostate Health: Studies have found that men who lose more than 11 pounds of body fat are more likely to have stable body fat percentages.

Compared to those with a weight change of ≤5 pounds, the risk of developing high-grade prostate cancer was significantly reduced starting at age 18.

An increase in body fat starting at age 50 significantly increases the risk of fatal prostate cancer.

Those with reduced blood volume have a significantly lower risk of developing prostate cancer.

Why does obesity increase the risk of cancer?

Traditional theory holds that adipose tissue functions through endocrine, autocrine, and paracrine pathways.

The endocrine and metabolically active organ, the occurrence and development of tumors may be related to the synthesis of sex hormones and steroid hormones.

It is related to the formation and bioavailability of insulin, insulin-like growth factor, leptin, and growth hormone.

It is associated with the release of pro-inflammatory cytokines and abnormal energy expenditure, especially insulin-like growth factor.

Alterations can disrupt the normal balance between cell proliferation, differentiation, and apoptosis.